THE SINGLE BEST STRATEGY TO USE FOR PKRRATING

The interfacial residues are highly conserved amongst eIF2α kinases and mutagenesis implicates the BTB dimer in PKR function18. FRET measurements demonstrate which the kinase domains dimerize when PKR binds to activating dsRNAs19. These observations aid a model where activating RNA serves for a scaffold to bind several PKR monomers, increasing the

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